Isaac made an earnest appeal to Adonai for his wife because she was ‘childless’ or ‘barren.’ This prayer had a two-fold purpose. First, he prayed for his wife because it was his responsibility to uphold her in prayer. The greatest action a husband can do on behalf of his wife is pray for her. A woman’s barrenness may not be for literal children, but to be set free from a spiritual barrenness.